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We all are aware about the benefits of silymarin, but it is important to know about the active compound in silymarin i.e. silibinin, Isosilybin A and Isosilybin B. While buying any silymarin (Milk Thistle) product, it is important to know the content of Silibinin, Isosilybin A and Isosilybin B, to make sure about the effectiveness of product.
Ultra Silymarin contains Milk Thistle seed flavonoids, including the important Silymarin fractions isosilybinins A and B, silybinins A and B, silychristin and silydianin. This particular group of flavonoids, collectively known as Silymarin.
Hundreds of research stands the efficacy of silymarin (milk thistle) against various liver disease and prostate disease. Clinical studies show that Silymarin has a protective, antioxidant effect on the liver, fortifying it against the undesirable effects of alcohol, smoke and harmful chemicals. Silymarin provides support and protection against liver toxins which can cause free-radical-mediated oxidative damage. Silymarin is many times more potent in antioxidant activity than vitamin E. In addition, it increases liver production of glutathione and protects red blood cell membranes against lipid peroxidation and hemolysis.
=> Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.
=> Silibinin is the main biologically active flavonolignan extracted from the seeds and fruits of milk thistle and has potential efficacy in the treatment of liver disease. In conclusion, we have demonstrated the effect of CsA and liver cirrhosis on the pharmacokinetics of silibinin in rats.
=> Silibinin Sensitizes Human Glioma Cells to TRAIL-Mediated Apoptosis via DR5 Up-regulation and Down-regulation of c-FLIP and Survivin .
=> Isosilybin Ainduces apoptosis in human prostate cancer cells via targeting Akt, NF-?B, and androgen receptor signaling.
=> Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells.
=> Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway.
=> Isosilybin B exhibits preferential growth inhibition of hormone-independent DU145 human prostate carcinoma cells. Isosilybin B also inhibits cell growth in androgen-independent PC3 and androgen-dependent LNCaP human prostate carcinoma cells.
=> Inhibitory effects of silibinin on cytochrome P-450 enzymes in human liver microsomes.
=> Efficacy of silibinin capsules in treating 50 patients with nonalcoholic fat liver.Click here to view research Report.
=> This study demonstrates a combined effectiveness of silibinin on improving liverand myocardial injury in experimental nonalcoholic fatty liver disease.
=> Our study clearly confirms that silibinin, a natural hepatoprotectant, is efficient at improving injuries caused by a chronic liver disease. It also demonstrates for the first time that a therapeutic treatment with silibinin, administrated as a complex with phosphatidylcholine, is effective in reversing steatosis, inflammation, oxidative stress and insulin resistance.
Read the entire label and follow the directions carefully prior to use.
Take one (1) capsule daily with or without food, or as recommended by a healthcare practitioner. This premium quality extract is triple standardized to the main active compound, silymarin, but also standardized to three highly active isomers (silibinins, isosilybin A and B).
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
% Daily Value
Milk Thistle (Silybum marianum)-950 Mg.
Extract (seed) [std. to 80% Silymarin (760mg) by UV, 53% Silibinin (400 mg), and 15% Isosilybin A (115mg) and 15% Isosilybin B (115mg)]
**Daily Value not established.
Vegetable cellulose (capsule), silica, vegetable stearate, rice flour.
This product contains No milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, or corn. Contains No sugar, and no artificial sweetener, flavors, colors, or preservatives.
Store tightly closed in a cool, dry place.
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
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